| Registro completo |
| Provedor de dados: |
International Journal of Morphology
|
| País: |
Chile
|
| Título: |
Effect of Five Single Nucleotide Polymorphisms of ABCG5 and ABCG8 Genes on Ezetimibe Lipid-Lowering Response
|
| Autores: |
Caamaño,José M
Saavedra,Nicolás
Zambrano,Tomás
Lanas,Fernando
Salazar,Luis A
|
| Data: |
2012-06-01
|
| Ano: |
2012
|
| Palavras-chave: |
Ezetimibe
Cholesterol
ABCG5/G8
Polymorphisms
|
| Resumo: |
In this study we evaluated the possible association between five single nucleotide polymorphisms in ABCG5 (rs6720173) and ABCG8 (rs11887534, rs4148211, rs4148217 and rs6544718) genes and ezetimibe response in Chilean hypercholesterolemic subjects. A total of 60 non-related hypercholesterolemic subjects, aged 18 to 65 years old were included in this study. These subjects were treated with ezetimibe (10mg/day) during one month. The ABCG5 and ABCG8 genotypes were assessed by PCR-RFLP. The genotype distribution of the ABCG5/ABCG8 polymorphisms was in Hardy-Weinberg equilibrium. Our results showed that the investigated polymorphisms were not associated with the response to ezetimibe. Nevertheless, the T allele of rs6544718 polymorphism was related to higher baseline levels of LDL-cholesterol (p<0.001). In addition, the G allele for the rs4148211 polymorphism was associated with greater baseline concentrations of triglycerides (P=0.019). This allele was also associated with lower concentrations of HDL-cholesterol (P=0.027), after ezetimibe treatment. Our results suggest that the studied polymorphisms do not affect the therapeutic response to ezetimibe in the evaluated subjects.
|
| Tipo: |
Journal article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200055
|
| Editor: |
Sociedad Chilena de Anatomía
|
| Formato: |
text/html
|
| Fonte: |
International Journal of Morphology v.30 n.2 2012
|
